Diabetes and Other Causes


In the case of diabetes, dry mouth can occur due to a few different reasons:

  • High blood sugar levels:

    When blood glucose levels are consistently high in individuals with diabetes, it can lead to increased urination (polyuria) and subsequent dehydration. Dehydration can contribute to dry mouth.

  • Neuropathy:

    Diabetes can cause nerve damage, including damage to the nerves that stimulate saliva production. When these nerves are affected, it can result in decreased saliva production and dry mouth.
  • Medications:

    Many people with diabetes take medications to manage their condition. Some of these medications, such as certain antihyperglycemic drugs, may list dry mouth as a side effect.

Several medications used to manage diabetes can potentially cause dry mouth as a side effect. These may include:

  • Antihyperglycemic medications:

    Certain classes of antihyperglycemic drugs, such as dipeptidyl peptidase-4 (DPP-4) inhibitors, can sometimes lead to dry mouth. Examples of DPP-4 inhibitors include sitagliptin, saxagliptin, linagliptin, and alogliptin.
  • Sodium-glucose co-transporter-2 (SGLT2) inhibitors:

    While SGLT2 inhibitors are generally well-tolerated, they can occasionally cause dry mouth as a side effect. Commonly prescribed SGLT2 inhibitors include canagliflozin, dapagliflozin, and empagliflozin.
  • Tricyclic antidepressants (TCAs):

    TCAs are occasionally prescribed to manage neuropathic pain associated with diabetes. However, these medications can also cause dry mouth as a side effect. Examples of TCAs include amitriptyline, nortriptyline, and desipramine.

Other Medical Conditions

Dry Mouth can be caused by a variety of medical conditions, medications, and lifestyle factors. Some of the common diseases that can cause Dry Mouth include:


     People with HIV/AIDS often experience Dry Mouth as a side effect of their medications or due to infections.

  • Parkinson’s disease:

     Parkinson’s disease can affect the nerves that control the salivary glands, leading to Dry Mouth.

  • Alzheimer’s disease:

     Alzheimer’s disease can affect the part of the brain that controls salivary gland function, resulting in Dry Mouth.

  • Hypertension:

     Some medications used to treat high blood pressure can cause Dry Mouth as a side effect.

  • Depression and anxiety:

    Many medications taken to treat mental health conditions can adversely affect the body’s saliva production and cause Dry Mouth. When untreated this can exacerbate feelings of depression and anxiety leading to more isolation and embarrassment.

  • Dysplasia:

    A swallowing disorder where the affected individual may encounter great difficulty in moving food or liquids from the mouth to the stomach.

  • Hyposalivation:

    A condition characterized by the absence or significantly reduced production of saliva, often leading to persistent dry mouth symptoms.

Get Relief From Dry Mouth - Aquoral is:


Lipid-based spray lubricates and provides a protective shield that helps the oral mucosa retain moisture


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Small size fits in a pocket or purse; no need for mixing or frequent rinsing as with water-based formulations

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Convenient Packaging

Over-the-counter Dry Mouth products are often sold in large bottles due to the frequency of use. Prescription supersaturated calcium phosphate rinses come in foil packets which need to be mixed in a large quantity of water before use.

Aquoral comes in two convenient 10 mL spray bottles that easily fit in a pocket, purse, or on a night table.

No Rinse and Repeat

Many non-prescription Dry Mouth treatments and prescription supersaturated calcium phosphate rinses require rinsing and spitting out and should not be swallowed.

Aquoral is a discreet, easy-to-use spray.


Aquoral’s formulation provides long-lasting relief. Finally, a solution that lubricates AND forms a protective layer that keeps moisture in the oral cavity.

Delivering sustainable relief for up to 6 hours.

Provides Relief

Most saliva substitutes hydrate and lubricate the oral mucosa providing temporary relief of Dry Mouth.

Aquoral’s OGT formulation creates a protective shield which, when used alone or combined with other Dry Mouth treatments, can lock in moisture, and enhance effectiveness.

What is Dry Mouth?

Dry Mouth is a more serious medical condition than its name would suggest. In most cases, patients’ daily lives and oral health can be significantly compromised if their Dry Mouth is not discovered early and managed effectively. It can be caused or exacerbated by more than 700 medications, both over-the-counter and prescription. Patients with certain health conditions or medical treatments, such as Sjögren’s disease or head and neck cancer therapy often experience Dry Mouth.

Despite being a common medical condition, the signs and symptoms may go unnoticed in a routine oral exam. It has been reported that the incidence of Dry Mouth in the general population is as high as 65 percent.

Source: ADA Science Institute, C. (2017). Oral Health Topics: Dry Mouth (Dry Mouth). JADA. www.ada.org/en/member-center/oral-health-topics/Dry Mouth.