Causes:

In the case of diabetes, dry mouth can occur due to a few different reasons:
When blood glucose levels are consistently high in individuals with diabetes, it can lead to increased urination (polyuria) and subsequent dehydration. Dehydration can contribute to dry mouth.
Diabetes can cause nerve damage, including damage to the nerves that stimulate saliva production. When these nerves are affected, it can result in decreased saliva production and dry mouth.
Many people with diabetes take medications to manage their condition. Some of these medications, such as certain antihyperglycemic drugs, may list dry mouth as a side effect.
Several medications used to manage diabetes can potentially cause dry mouth as a side effect. These may include:
Certain classes of antihyperglycemic drugs, such as dipeptidyl peptidase-4 (DPP-4) inhibitors, can sometimes lead to dry mouth. Examples of DPP-4 inhibitors include sitagliptin, saxagliptin, linagliptin, and alogliptin.
While SGLT2 inhibitors are generally well-tolerated, they can occasionally cause dry mouth as a side effect. Commonly prescribed SGLT2 inhibitors include canagliflozin, dapagliflozin, and empagliflozin.
TCAs are occasionally prescribed to manage neuropathic pain associated with diabetes. However, these medications can also cause dry mouth as a side effect. Examples of TCAs include amitriptyline, nortriptyline, and desipramine.
Lipid-based spray lubricates and provides a protective shield that helps the oral mucosa retain moisture
Helps prevent mucosal damage & tooth decay while improving the ability to chew, taste, swallow, and speak
Small size fits in a pocket or purse; no need for mixing or frequent rinsing as with water-based formulations


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Over-the-counter Dry Mouth products are often sold in large bottles due to the frequency of use. Prescription supersaturated calcium phosphate rinses come in foil packets which need to be mixed in a large quantity of water before use.
Aquoral comes in two convenient 10 mL spray bottles that easily fit in a pocket, purse, or on a night table.
Many non-prescription Dry Mouth treatments and prescription supersaturated calcium phosphate rinses require rinsing and spitting out and should not be swallowed.
Aquoral is a discreet, easy-to-use spray.
Aquoral’s formulation provides long-lasting relief. Finally, a solution that lubricates AND forms a protective layer that keeps moisture in the oral cavity.
Delivering sustainable relief for up to 6 hours.
Most saliva substitutes hydrate and lubricate the oral mucosa providing temporary relief of Dry Mouth.
Aquoral’s OGT formulation creates a protective shield which, when used alone or combined with other Dry Mouth treatments, can lock in moisture, and enhance effectiveness.
Dry Mouth is a more serious medical condition than its name would suggest. In most cases, patients’ daily lives and oral health can be significantly compromised if their Dry Mouth is not discovered early and managed effectively. It can be caused or exacerbated by more than 700 medications, both over-the-counter and prescription. Patients with certain health conditions or medical treatments, such as Sjögren’s disease or head and neck cancer therapy often experience Dry Mouth.
Despite being a common medical condition, the signs and symptoms may go unnoticed in a routine oral exam. It has been reported that the incidence of Dry Mouth in the general population is as high as 65 percent.
Source: ADA Science Institute, C. (2017). Oral Health Topics: Dry Mouth (Dry Mouth). JADA. www.ada.org/en/member-center/oral-health-topics/Dry Mouth.