Dry Mouth from Antidepressants

Dry mouth, or xerostomia, is a common yet often overlooked side effect of many medications, including antidepressants. It is estimated that up to 46 percent of patients taking antidepressants experience dry mouth as a side effect. This can be uncomfortable and have negative impacts on oral health, so it's important to understand why this happens and how to manage it.

Understanding Antidepressants and Dry Mouth

Popular Types of Antidepressants

Antidepressants are utilized for managing depression and anxiety, with Wellbutrin, Lexapro, and Zoloft being among the most prescribed. While effective for mental health treatment, these medications can disrupt normal saliva production leading to dry mouth.

Other medications that can cause dry mouth include certain antihistamines, muscle relaxants, and blood pressure medications.

Why Antidepressants Can Cause Dry Mouth

Antidepressants can affect the body's muscarinic receptors which play a role in saliva secretion. As a result, patients may experience dry mouth symptoms including difficulty swallowing, sore throat, and a significant impact on their oral health.

This side effect is also seen with other medications like trazodone, contributing to the overall concentration of trazodone dry mouth cases.

How Aquoral Treats Dry Mouth

Aquoral Protective Oral Spray is specially formulated to provide lasting protection against dry mouth symptoms caused by antidepressants. By forming a protective film over the whole of the mucous membranes of the mouth,

Aquoral helps maintain oral moisture, offering relief from the discomfort such as with dry mouth caused by zoloft and other antidepressant-related dry mouth conditions.

The Science Behind Aquoral

Aquoral's unique formula targets the core issue of reduced saliva production. It provides a soothing, lubricating layer over mucous membranes in the mouth, protecting it from the dryness and irritation symptomatic of antidepressant xerostomia.

Understanding the Long-Term Effects of Dry Mouth

Unchecked, dry mouth can lead to severe dental health issues, including tooth decay, gum disease, and mouth infections.

It's crucial for patients experiencing dry mouth from antidepressants to seek treatment to mitigate these risks and preserve their oral health over the long term.

Seeking Treatment and Getting Help

Taking action and seeking treatment with Aquoral can significantly improve your quality of life if you're battling dry mouth due to antidepressants. Not only does Aquoral aim to alleviate immediate discomfort, but it also offers a proactive approach to safeguard your dental health against long-term complications such as tooth decay and gum disease.

By adding Aquoral to your daily regimine, you're not just treating dry mouth—you're taking a step towards preserving your oral health, enhancing your ability to eat, speak, and smile with confidence. Don't let dry mouth caused by medication take away your comfort. Try Aquoral and experience the relief and protection your mouth deserves.

How to Seek Treatment with Aquoral

If you're experiencing dry mouth from antidepressants like Wellbutrin or Lexapro, know that relief is within reach. Aquoral Protective Oral Spray is available through prescription.

We encourage patients to contact us and discuss the benefits of Aquoral in combating dry mouth associated with antidepressant use.

Aquoral is committed to improving the quality of life for those dealing with the side effects of necessary medication. Contact us today to learn more about how Aquoral can support your oral health during antidepressant treatment.

Relief From Antidepressant Xerostomia - Aquoral is:


Lipid-based spray lubricates and provides a protective shield that helps the oral mucosa retain moisture


Helps prevent mucosal damage & tooth decay while improving the ability to chew, taste, swallow, and speak

Fast & Long-lasting

Two quick sprays provide rapid relief that lasts for 4 to 6 hours, and reduces the need for frequent dosing

Easy to Use

Small size fits in a pocket or purse; no need for mixing or frequent rinsing as with water-based formulations

best mouth spray for dry mouth
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We will bring you to our secure portal to complete your medical review which will be completed within 24 hours. Free standard shipping will apply. Expedited shipping may be requested. Select states may be subject to a video call.

Convenient Packaging

Over-the-counter Dry Mouth products are often sold in large bottles due to the frequency of use. Prescription supersaturated calcium phosphate rinses come in foil packets which need to be mixed in a large quantity of water before use.

Aquoral comes in two convenient 10 mL spray bottles that easily fit in a pocket, purse, or on a night table.

No Rinse and Repeat

Many non-prescription Dry Mouth treatments and prescription supersaturated calcium phosphate rinses require rinsing and spitting out and should not be swallowed.

Aquoral is a discreet, easy-to-use spray.


Aquoral’s formulation provides long-lasting relief. Finally, a solution that lubricates AND forms a protective layer that keeps moisture in the oral cavity.

Delivering sustainable relief for up to 6 hours.

Provides Relief

Most saliva substitutes hydrate and lubricate the oral mucosa providing temporary relief of Dry Mouth.

Aquoral’s OGT formulation creates a protective shield which, when used alone or combined with other Dry Mouth treatments, can lock in moisture, and enhance effectiveness.

What is Dry Mouth?

Dry Mouth is a more serious medical condition than its name would suggest. In most cases, patients’ daily lives and oral health can be significantly compromised if their Dry Mouth is not discovered early and managed effectively. It can be caused or exacerbated by more than 700 medications, both over-the-counter and prescription. Patients with certain health conditions or medical treatments, such as Sjögren’s disease or head and neck cancer therapy often experience Dry Mouth.

Despite being a common medical condition, the signs and symptoms may go unnoticed in a routine oral exam. It has been reported that the incidence of Dry Mouth in the general population is as high as 65 percent.

Source: ADA Science Institute, C. (2017). Oral Health Topics: Dry Mouth (Dry Mouth). JADA. Mouth.